Chris
Destache
Pharm. D.
Professor
Vice Chair
Pharmacy Practice
Email:
destache@creighton.edu
(402) 280-4744
Additional Roles:
Vice Chair for Research, Pharmacy Practice Department
Instructor in:
Pharmacotherapeutics 4, Elective infectious disease clerkship 1, Elective infectious disease clerkship 2, Pharmacotherapeutics I, Pharmacotherapeutic case studies I, Pharmacotherapeutics II, Pharmacotherapeutics case studies II
Biography:
Pharm. D. Creighton University (1984) Fellowship, Creighton University Department of Family Practice (1984-85)
Publications:
Date AA, Shibata A, Goede M, Sanford B, DeBoer J, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis. Antivir Res 2012 doi: 10.1016/j.antiviral.2012.09.015 [Epub ahead of print].
Destache CJ, Goede M,
Belgum T. Antiretroviral
nanoparticles: An extended drug delivery modality. Spotlight article. Therapeutic Delivery. 2010;1:383-386.
Destache CJ, Goede M,
Belgum T, Shibata A, Belshan MA.
Pharmacokinetics of antiretroviral release from PLGA nanoparticles
in mice. J Antimicob Chemother 2010;65:2183-2187. doi: 10.1093/jac/dkq318.
Destache CJ, Belgum T,
Christensen K, Shibata A, Sharma A, Dash AK. Combination antiretroviral drugs in PLGA nanoparticle
for HIV-1. BMC Infect Dis 2009;9:198.
Kingsley JD, Dou H, Morehead J, Gorantla S, Rabinow B, Gendelman HE, Destache CJ. Nanotechnology: A focus on nanoparticles as a drug delivery system. J Neuroimmun Pharmacol 2006;1:340-350.
Dou H, Morehead J, Destache CJ, Kingsley JD, Skyakhtenko L, Zhou U, Chaubal M, Werling J, Kipp J, Rabinow B, Gendelman HE. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages. Virol 2006: Sep 21; [Epub ahead of print].
Gorantla S, Dou H, Boska M, Destache CJ, Nelson J, Poluektova L, Rabinow B, Gendelman HE, Mosley RL. Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery. J Leuko Biol 2006;Aug 14:[Epub ahead of print].
Dou H, Destache CJ, Morehead JR, Mosley RL, Boska MD, Kingsley J, Gorantla S, Poluektova L, Nelson JA, Chaubal M, Werling J, Kipp J, Rabinow B, Gendelman HE. A macrophage nanoparticle system for anti-retroviral drug delivery: Pharmacokinetic, immune and anti-viral responses in a murine model of HIV-1 disease. Blood 2006 Jun 29; [Epub ahead of print].
Benner EJ, Mosley RL, Destache CJ, Nemechek C, Lewis TB, Gorontha S, Jackson-Lewis V, Green S, Przedborski S, Gendelman HE. Therapeutic immunization protects dopaminergic neurons in an MPTP mouse model of Parkinson’s disease. Proc Nat Acad Sci 2004;101:9435-9440.
Research Interests:
nanomedicine, HIV, Infectious Diseases
Hixson-Lied Bldg. Room 114
School of Pharmacy & Health Professions
2500 California Plaza
Omaha,
NE
68178
Fax:
(402) 280-3320
Pager:
|