Chris
Destache
Professor of Pharmacy Practice, (1985; 1994), Professor of Medicine (1985; 1995), Professor of Medical Microbiology
Pharm. D.
Pharmacy Practice
Email:
destache@creighton.edu
402 280-4744
Biography:
Pharm. D. Creighton University (1984) Fellowship, Creighton University Department of Family Practice (1984-85)
Publications:
1. Kingsley JD, Dou H, Morehead J, Gorantla S, Rabinow B, Gendelman HE, Destache CJ. Nanotechnology: A focus on nanoparticles as a drug delivery system. J Neuroimmun Pharmacol 2006;1:340-350.
2. Dou H, Morehead J, Destache CJ, Kingsley JD, Skyakhtenko L, Zhou U, Chaubal M, Werling J, Kipp J, Rabinow B, Gendelman HE. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages. Virol 2006: Sep 21; [Epub ahead of print].
3. Gorantla S, Dou H, Boska M, Destache CJ, Nelson J, Poluektova L, Rabinow B, Gendelman HE, Mosley RL. Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery. J Leuko Biol 2006;Aug 14:[Epub ahead of print].
4. Dou H, Destache CJ, Morehead JR, Mosley RL, Boska MD, Kingsley J, Gorantla S, Poluektova L, Nelson JA, Chaubal M, Werling J, Kipp J, Rabinow B, Gendelman HE. A macrophage nanoparticle system for anti-retroviral drug delivery: Pharmacokinetic, immune and anti-viral responses in a murine model of HIV-1 disease. Blood 2006 Jun 29; [Epub ahead of print].
5. Benner EJ, Mosley RL, Destache CJ, Nemechek C, Lewis TB, Gorontha S, Jackson-Lewis V, Green S, Przedborski S, Gendelman HE. Therapeutic immunization protects dopaminergic neurons in an MPTP mouse model of Parkinson’s disease. Proc Nat Acad Sci 2004;101:9435-9440.
6. Enose Y, Destache CJ, Mack AL, Anderson JR, et al. Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations. Glia 2005;51(3):161-172.
7. Boska MD, Lewis TB, Destache CJ, Benner EJ, Nelson JA, Uberti M, Mosley RL, Gendelman HE. Quantitative 1H magnetic resonance spectroscopic imaging determine therapeutic immunization efficacy in an animal model of Parkinson's disease. J Neurosci 2005;25(7):1671-1700.
8. Carlson KA, Ciborowski P, Schellpeper CN, Biskup TM, Shen RF, Luo X, Destache CJ, Gendelman HE. Proteomic Fingerprinting of HIV-1-infected Human Monocyte-Derived Macrophages: A Preliminary Report. J Neuroimmunol 2004;147:35-42.
9. Gendelman HE, Destache CJ, Zelivyanskaya ML, Nelson JA, Boska MD, Biskup TM, McCathy MK, Carlson KA, Nemechek CR, Benner EJ, Mosley RL. Neuroimaging and Proteomic Tracking of Neurodegeneration in MPTP-Treated Mice. Annuals of the New York Academy of Sciences. 2003;122:21-23.
Instructor in:
Pharmacotherapeutics 4, Elective infectious disease clerkship 1, Elective infectious disease clerkship 2, Pharmacotherapeutics I, Pharmacotherapeutic case studies I, Pharmacotherapeutics II, Pharmacotherapeutics case studies II
Research Interests:
HPLC, nanomedicine, pharmacogenetics
office:
Hixon-Lead Bldg Rm 114, School of Pharmacy & Allied Health Professions, 2500 California Plaza, Omaha, NE 68178
office_hrs:
Fax:
402 280-3320
Pager:
|